28-DAY REPEATED ORAL TOXICITY STUDY OF A HYPOLIPIDEMIC AGENT, NK-104 IN RATS

Oral toxicity of indium in rats: single and 28-day repeated administration studies.

Indium is widely used in the electronics industry to make semiconductors, liquid-crystal panels, and plasma display panels, and its production is increasing. However, it is necessary to handle it more cautiously than before, because the pulmonary toxicity of inhaled indium has been identified. The present study aimed to characterize the potential toxic effects of indium through oral administrat...

Oral toxicity of bismuth in rat: single and 28-day repeated administration studies.

The consumption and production of bismuth are increasing, however there is very little information about the direct toxic effect of bismuth. The present study aimed to characterize the potential toxic effects of bismuth through oral administration and observation for fourteen days following single dose of 0 and 2,000 mg/kg (acute oral toxicity study), and repeated oral administration for twenty...

Sub-chronic Oral Toxicity Test Repeated Dose 90 - Day Oral Toxicity Study in Non-rodents

Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats

BACKGROUND Nuna Kadugu (NK), a Siddha medicine prepared from leaves and fruits of Morinda Pubescens, used for the treatment of various skin diseases. Though NK has been widely used for several decades, no scientific report was available on its safety. Present study was undertaken to demonstrate the oral toxicity of NK in Sprague Dawley rats. METHODS Acute and 28-day repeated oral toxicity stu...

Evaluation of Arecoline Hydrobromide Toxicity after a 14-Day Repeated Oral Administration in Wistar Rats

A subchronic toxicity test was conducted in rats on the basis of a previous acute toxicity test to evaluate the safety of arecoline hydrobromide (Ah), to systematically study its pharmacological effects and to provide experimental support for a safe clinical dose. Eighty rats were randomly divided into four groups: a high-dose group (1000 mg/kg), medium-dose group (200 mg/kg), low-dose group (1...